Senior Scientist Job at Deciphr Health, Santa Clara, CA

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  • Deciphr Health
  • Santa Clara, CA

Job Description

About Us Deciphr Health is a seed-stage biotech developing programmable DNA nanostructures for next-generation point-of-care diagnostics. Our first clinical application targets preeclampsia screening — a condition that affects 1 in 25 pregnancies with no adequate rapid test. We're building from our R&D lab in San Carlos, CA.

The Role You'll own the aptamer discovery pipeline end-to-end: from SELEX campaign design through NGS-based candidate selection to biochemical characterization of lead binders. This is a hands-on bench role with high autonomy — you'll be the team's go-to expert on nucleic acid selection, modification, and bioconjugation. You'll also contribute to our broader DNA nanostructure platform (with internal training provided).

What You'll Do

  • Design and run SELEX campaigns (affinity-based and capture-release formats) against clinically relevant protein targets
  • Perform site-specific bioconjugation of oligonucleotides to proteins, fluorophores, and surface chemistries
  • Purify and QC modified oligos and conjugates (HPLC, FPLC, spin-column)
  • Prepare and manage NGS libraries to identify top aptamer candidates from selection rounds
  • Monitor selections via qPCR/RT-PCR and develop binding validation assays
  • Support fabrication and testing of DNA nanodevices following internal protocols

What We're Looking For

  • PhD in Biochemistry, Molecular Biology, Chemistry, or related field — or MS with 3–5+ years of hands-on industry experience
  • Deep, demonstrated expertise in SELEX (not just familiarity — you've run campaigns)
  • Strong oligo handling skills: purification, chemical modification, conjugation chemistry
  • Proficiency with HPLC, qPCR, and NGS library prep workflows
  • Comfort working in a startup environment with minimal infrastructure and high ownership

Nice to Have

  • Exposure to DNA nanotechnology or structural DNA assembly
  • Experience with phage display, cell-SELEX, or tissue-based selections
  • HPLC instrument maintenance and troubleshooting

Compensation Base salary commensurate with experience + meaningful early-stage equity.

Location San Carlos, CA (on-site; this is a lab-based role).

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