Job Description

Are you ready to join Connecticut Innovation’s vibrant community of innovators? Connecticut Innovations (“CI”) is Connecticut’s strategic venture capital arm, and we are passionate about serving our portfolio of 220+ companies across various industries, with strengths in life sciences, technology, and climate tech.

Come join encapsulate.bio | as a Lab Technician - Tissue Culture & Organoid Biology (Oncology)!

Encapsulate Overview

Encapsulate Bio is a translational oncology biotechnology company developing advanced 3D tumor organoid and microphysiological systems to accelerate drug discovery and precision medicine. Our platforms integrate patient-derived models, high-content imaging, molecular biology, and functional assays to better predict therapeutic response and uncover novel biology.

We are building next-generation experimental pipelines that connect molecular profiling with functional phenotypes at scale — and we're looking for a skilled Tissue Culture Technician to support this mission at the bench.

Lab Technician - Tissue Culture & Organoid Biology (Oncology) | Job Description

We are seeking a motivated and detail-oriented Tissue Culture Technician with hands-on experience in cell culture and a strong interest in 3D biology, organoid systems, and cancer research. This individual will be a core contributor to day-to-day laboratory operations, executing tissue culture workflows, supporting assay development, and maintaining the high-quality experimental standards our platforms depend on.

This is a great opportunity for someone who takes pride in precise, reproducible bench work and wants to grow their skills in a cutting-edge biotech environment.

Key Responsibilities

• Perform routine and advanced cell culture including 2D monolayer and 3D organoid/spheroid systems using established protocols
• Assist in the culture and maintenance of patient-derived cancer organoids/tumoroids under direct supervision
• Carry out molecular biology techniques including DNA/RNA extraction, qPCR, and basic sequencing workflows
• Support histology and imaging workflows including fixation, embedding, sectioning, and IF/IHC staining
• Execute functional assays measuring viability, proliferation, drug response, and apoptosis
• Maintain accurate and thorough experimental records and contribute to SOP documentation
• Assist in reagent preparation, inventory management, and general lab maintenance
• Collaborate with scientists and cross-functional team members to support ongoing research projects
• Contribute to troubleshooting culture and assay performance issues

Required Qualifications

• Bachelor's or Master's degree in Biology, Cell Biology, Biochemistry, or a related life science field
• Hands-on experience with mammalian cell culture (coursework, research, or industry)
• Strong attention to detail and commitment to reproducible, high-quality bench work
• Good laboratory documentation and organizational skills
• Eagerness to learn new techniques and work in a fast-paced startup environment

Preferred Qualifications

• Experience with 3D cell culture, organoids, or spheroids
• Familiarity with cancer biology or translational research
• Exposure to histology, IF/IHC, or tissue-based assays
• Experience with fluorescence or brightfield microscopy
• Familiarity with image analysis tools (ImageJ/Fiji, CellProfiler, or similar)
• Experience with multi-well format assays (96- / 384-well plates)
• Prior experience in a biotech, pharmaceutical, or academic research lab setting

What We Offer

• Hands-on training in cutting-edge organoid and translational biology platforms
• A supportive, collaborative team environment with opportunities to grow your technical skillset
• Real contribution to meaningful oncology research
• Competitive compensation and benefits

EQUAL OPPORTUNITY EMPLOYER

Connecticut Innovations and its portfolio companies are an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. We have strict wage minimums, generous benefits, and personal leave policies. Our goal is to provide safe, rewarding, and empowering work environments for all who interact with our company and/or portfolio companies.

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